Glutathione S-transferase M1-T1 null genotypes and susceptibility to Hodgkin’s lymphoma
نویسندگان
چکیده
منابع مشابه
Combined glutathione S transferase M1/T1 null genotypes is associated with type 2 diabetes mellitus
BACKGROUND Due to new genetic insights, a considerably large number of genes and polymorphic gene variants are screened and linked with the complex pathogenesis of type 2 diabetes (DM). Our study aimed to investigate the association between the two isoforms of the glutathione S-transferase genes (Glutathione S transferase isoemzyme type M1- GSTM1 and Glutathione S transferase isoemzyme type T1-...
متن کاملFrequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia.
Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion variants that are associated with a lack of e...
متن کاملLarynx cancer risk in relation to glutathione S-transferase M1 and T1 genotypes and tobacco smoking.
Glutathione S-transferase (GST) isoenzymes are involved in the detoxification of several tobacco smoke-derived carcinogens. It is thus conceivable that deficiency in GST activity due to homozygous deletion of the GSTM1 and GSTT1 genes (the null genotypes) may modulate susceptibility to smoking-induced cancers. The effects of the GSTM1 and GSTT1 null genotypes on laryngeal cancer risk were evalu...
متن کاملprevalence of null genotypes of glutathione s-transferase t1 (gstt1) and m1 (gstm1) in seven iranian populations
background: previous studies have revealed significant differences between populations for genotypic frequencies of glutathione s-transferase t1 ( gstt1 ) and m1 ( gstm1 ) polymorphisms. in order to find the frequency of the null genotypes of gstm1 and gstt1 in iranian populations, the present study was carried out. methods: the total study subjects consisted of 1340 unrelated healthy muslims/i...
متن کاملAssociation of glutathione S-transferase M1 and T1 polymorphisms and temperament
Mizaj (Temperament) is one of the basic concepts of Iranian Traditional Medicine (ITM), which has great importance in diagnosis and treatment of diseases, as well as maintaining the ideal healthy state of an individual. However, very little is known about the biological mechanisms of mizaj dependence treatment in practical ITM. This study was aimed to evaluate any association between the mizaj ...
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ژورنال
عنوان ژورنال: ABI Genetika
سال: 2017
ISSN: 0534-0012,1820-6069
DOI: 10.2298/gensr1703911m